The AC supply in itself doesn't cause screws to loosen. However the vibration at 50Hz caused by electro-magnetic effects in transformers (in particular) certainly can. It is particularly likely when a screw connection block (chocolate bar) is mounted directly on a power transformer in the 50-500W sort of range.
Loose connections in domestic plugs/sockets are common, but are due to mechanical creep. Stranded wire which has been 'tinned' with solder is particularly prone because the solder is soft and compresses over time. Better practice is to use 'boot-lace' crimps ....or simply leave the twisted wire bare. A more fundamental issue is that in very many domestic wiring accessories the grub-screws/fittings have a thread which is much too course, and often very poorly machined. Ideally they should be a much finer thread with an appropriately shaped contact face on the screw.
Loose connections in domestic plugs/sockets are common, but are due to mechanical creep. Stranded wire which has been 'tinned' with solder is particularly prone because the solder is soft and compresses over time. Better practice is to use 'boot-lace' crimps ....or simply leave the twisted wire bare. A more fundamental issue is that in very many domestic wiring accessories the grub-screws/fittings have a thread which is much too course, and often very poorly machined. Ideally they should be a much finer thread with an appropriately shaped contact face on the screw.