Air con makes vary little difference to fuel consumption and as already suggested running it frequently does pay dividends.
My Brother-in-Law has an S type Jag which due to his working away from home only get's used at weekends. He went to France on holiday last year and that was a nightmare. On the way down the aircon compressor siezed from lack of use. He had to use two hire cars while on holiday in france, then do a walking passenger transfer with all the luggage and two kids to get back to uk, hire a car at the ferry port to get home and then a week after his holiday nightmare he had to ring me at 4am as the taxi had not shown up to take him 60 miles to Birmingham airport. Then he flew to Lyon, taxi to the garage, drive car after paying 2200 euro's for the repair, to Calais. While he was on route we booked him a ferry ticket to coincide with his arrival at Calais (£98 one way). Then he drove 350 miles to Leominster. All told he was up for 30 hours straight and with rentals hotel rooms etc, he was about £3500 out of pocket.
He has now taught his OH who can't drive, to start the car switch aircon on and run for 10 mins every other day. It's cheaper than the repair bill for the next three years!!!!!!!!
As my Rover has a simlar compressor you can guess what I do. And I still get upto 64 Mpg solo and 37Mpg towing when we move sites twice annually at present.