There are several theories about the difference between car and caravan wheel fixings, and as far as I know there hasn't been a definitive explanation. To be fair there haven't been many recent reports, whether that's due to changes that some manufacturers made to the fixings and the advised torque settings , or whether it's down to caravanners heeding the advice and rechecking the fasteners.
It's not a foregone conclusion that trailer hubs are the same as caravan hubs
Do cars carry more weight on their wheels? I suspect that if you do the maths SA caravans may well carry more weight than any tow car wheel, which is why caravan tyres often have a higher load rating.
Thinking scientifically a 1,500kg caravan is carried mostly one one axle (or two, close together). On a single axle van that's most of the weight (less the nose weight) on two wheels. The tow car is, say, 1,800 kg carried across two widely-spaced axles, so nominally 900 kg per axle (plus the load, including nose weight). The dynamic load will vary on each axle due to acceleration and braking events - a single axle van will not experience this.
Also, caravan wheels tend to be smaller than car wheels, so spin faster for a given road speed.
Car wheels tend to have to accommodate higher lateral loading - a car can corner quite a lot more quickly than a caravan will.
Car wheels have to be able to take acceleration and deceleration torque - a van's wheels only experience braking torque (and, I suspect, nowhere near the maximum braking torque that a car wheel can suffer).
So all-in-all I'd say that the increased load and smaller diameter would be significant factors in determining wheel and tyres specifications and maintenance, but there's no doubt more to it than my top-of-the-head musings.