Did Plymouth-Santander and return this August. Spent two weeks in Cantabria (camping Playa de Oyambre, www.oyambre.com).
Ferry journey is excellent, we were lucky enough to get the Pont Aven which is Brittany Ferries flagship. Embarking very efficient in Plymouth, Santander was a bit chaotic!. Ships very modern and well equipped (bars, estaurants, shops, cinema, swimming pool, play areas, even the entertainment was good in the evening. We had a standard outside cabin which is compact but functional with en-suite, A/C etc. Supposed to sleep 4 but we squashed 5 of us in there as our children are small and otherwise it would have meant one of us using a recliner chair. Very little engine noise during night in cabins, likewise none from bars, all in all a very peaceful nights sleep. We saw dolphins on the way across too.
Outward crossing was like a millpond, on return trip the Bay of Biscay was a bit choppy and embarassingly I suffered a bit but wife & kids were fine!
I'd do it again certainly, it's not cheap (cost us about
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