I strongly suspect the biggest indicator that a driver would be aware of is the
apparent change in engine power when the AC cuts in, and how bigger change that is will vary depending on the vehicle.
Attempting to give a measurable difference outside of a lab will be difficult. In real life I'd be surprised if you could could detect a change in instantaneous MPG measurements, there are simply too many other real world variables.
I'm not about suggest you should attempt this on public roads, but if it were possible to run at max speed on a flat wind free surface then switching AC on, you would see the top speed drop.
It should be enough to know that as AC systems need power to operate that a car that power has to come from the fuel used in the car, and that means the fuel used to power the AC will detract form the vehicles range.
Due to the inherent inefficiencies of In ICE vehicles and the large fuel capacity the fuel used to power the AC the losses are less noticeable, but in an EV where the high efficency of the motor means any reduction in the battery charge available to drive the car will be more noticable.